Clinical Epidemiology: Practice and Methods (Methods in Molecular Biology)

 Epidemiology  Comments Off on Clinical Epidemiology: Practice and Methods (Methods in Molecular Biology)
Dec 072019
 

Focusing on improving the diagnosis, prognosis, and management of human disease, this book takes on the issues of research design, measurement, and evaluation which are critical to clinical epidemiology. This second edition of Clinical Epidemiology: Practice and Methods opens with how best to frame a clinical research question, the ethics associated with doing a research project in humans, and the definition of various biases that occur in clinical research. From there, it continues by examining issues of design, measurement, and analysis associated with various research designs, including determination of risk in longitudinal studies, assessment of therapy in randomized controlled clinical trials, and evaluation of diagnostic tests, and then delves into the more specialized area of clinical genetic research, before concluding with basic methods used in evidence-based decision making including critical appraisal, aggregation of multiple studies using meta-analysis, health technology assessment, clinical practice guidelines, development of health policy, translational research, how to utilize administrative databases, and knowledge translation. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and practical advice to ensure real world success.
Comprehensive and authoritative, Clinical Epidemiology: Practice and Methods, Second Edition is intended to educate researchers on how to undertake clinical research and should be helpful not only to medical practitioners but also to basic scientists who want to extend their work to humans, to allied health professionals interested in scientific evaluation, and to trainees in clinical epidemiology.

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Diseases of Poverty: Epidemiology, Infectious Diseases, and Modern Plagues

 Epidemiology, Infectious Diseases  Comments Off on Diseases of Poverty: Epidemiology, Infectious Diseases, and Modern Plagues
Dec 072019
 

Only a few decades ago, we were ready to declare victory over infectious diseases. Today, infectious diseases are responsible for significant morbidity and mortality throughout the world.

This book examines the epidemiology and social impact of past and present infectious disease epidemics in the developing and developed world. In the introduction, the authors define global health as a discipline, justify its critical importance in the modern era, and introduce the Millennium Development Goals, which have become critical targets for most of the developing world. The first half of the volume provides an epidemiological overview, exploring early and contemporary perspectives on disease and disease control. An analysis of nutrition, water, and sanitation anchors the discussion of basic human needs. Specific diseases representing both “loud” and “silent” emergencies are investigated within broader structures of ecological and biological health such as economics, education, state infrastructure, culture, and personal liberty. The authors also examine antibiotic resistance, AIDS, malaria, tuberculosis, and pandemic influenza, and offer an epilogue on diseases of affluence, which now threaten citizens of countries both rich and poor.

A readable guide to specific diseases, richly contextualized in environment and geography, this book will be used by health professionals in all disciplines interested in global health and its history and as a textbook in university courses on global health.

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Human Genome Epidemiology, 2nd Edition

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Dec 032019
 

The first edition of Human Genome Epidemiology, published in 2004, discussed how the epidemiologic approach provides an important scientific foundation for studying the continuum from gene discovery to the development, applications and evaluation of human genome information in improving health and preventing disease. Since that time, advances in human genomics have continued to occur at a breathtaking pace. With contributions from leaders in the field from around the world, this new edition is a fully updated look at the ways in which genetic factors in common diseases are studied. Methodologic developments in collection, analysis and synthesis of data, as well as issues surrounding specific applications of human genomic information for medicine and public health are all discussed. In addition, the book focuses on practical applications of human genome variation in clinical practice and disease prevention. Students, clinicians, public health professionals and policy makers will find the book a useful tool for understanding the rapidly evolving methods of the discovery and use of genetic information in medicine and public health in the 21st century.
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Immunoepidemiology

 Epidemiology, Immunology  Comments Off on Immunoepidemiology
Nov 252019
 

This textbook focuses on the nascent field of Immunoepidemiology that addresses how differences in immune responses among individuals affect the epidemiology of infectious diseases, cancer, hypersensitivity, and autoimmunity. The idea for the book originated from a course entitled “Immunology for Epidemiologists“ at the Yale School of Public Health. While many fine textbooks are available that address the immunological responses of individuals to pathogens, these provided very little information regarding how immunological variation among populations affects the epidemiology of disease. And yet, it has long been recognized that there is great immunologic diversity among people, which can have a profound effect on the epidemiology of disease. Careful review of the immunologic and epidemiologic literature revealed that there have been relatively few publications concerning immunoepidemiology and that no textbook is available on the subject. This textbook therefore aims to fill this void by providing a much-needed tool to comprehensively and efficiently teach immunoepidemiology. The book includes a section on the basic principles of immunology, and then applies them to particular examples of disease in human populations. The target audience for this text book are Masters of Public Health students. Others who should also find it of interest include PhD students in epidemiology, immunology, medical students, generalists, and specialists in immunology, infectious diseases, cancer, and rheumatology.

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Practical Healthcare Epidemiology: Third Edition

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Nov 222019
 

In recent years, issues of infection prevention and control, patient safety, and quality-of-care have become increasingly prominent in healthcare facilities. Practical Healthcare Epidemiology takes a practical, hands-on approach to these issues, addressing all aspects of infection surveillance and prevention in clear, straightforward terms. This fully revised third edition brings together the expertise of more than fifty leaders in healthcare epidemiology who provide clear, sound guidance on infection prevention and control for the full range of patients in all types of healthcare facilities, including those in settings with limited resources. A powerful resource for practitioners in any branch of medicine or public health who are involved in infection prevention and control, whether they are experienced in healthcare epidemiology or new to the field. “A handy desk reference and an up-to-date primer for trainees and experts alike” —The Journal of the American Medical Association “An essential for anyone in the field.”—Thomas R. Talbot, Chief Hospital Epidemiologist, Vanderbilt University Medical Center
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Mathematical Modeling of Biological Systems, Volume II: Epidemiology, Evolution and Ecology, Immunology, Neural Systems

 Epidemiology, Immunology  Comments Off on Mathematical Modeling of Biological Systems, Volume II: Epidemiology, Evolution and Ecology, Immunology, Neural Systems
Nov 182019
 

Volume II of this two-volume, interdisciplinary work is a unified presentation of a broad range of state-of-the-art topics in the rapidly growing field of mathematical modeling in the biological sciences. Highlighted throughout are mathematical and computational apporaches to examine central problems in the life sciences, ranging from the organization principles of individual cells to the dynamics of large populations. The chapters are thematically organized into the following main areas: epidemiology, evolution and ecology, immunology, neural systems and the brain, and innovative mathematical methods and education.
The work will be an excellent reference text for a broad audience of researchers, practitioners, and advanced students in this rapidly growing field at the intersection of applied mathematics, experimental biology and medicine, computational biology, biochemistry, computer science, and physics.

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Structured Population Models in Biology and Epidemiology

 Epidemiology  Comments Off on Structured Population Models in Biology and Epidemiology
Nov 142019
 

In this new century mankind faces ever more challenging environmental and publichealthproblems,suchaspollution,invasionbyexoticspecies,theem- gence of new diseases or the emergence of diseases into new regions (West Nile virus,SARS,Anthrax,etc.),andtheresurgenceofexistingdiseases(in?uenza, malaria, TB, HIV/AIDS, etc.). Mathematical models have been successfully used to study many biological, epidemiological and medical problems, and nonlinear and complex dynamics have been observed in all of those contexts. Mathematical studies have helped us not only to better understand these problems but also to ?nd solutions in some cases, such as the prediction and control of SARS outbreaks, understanding HIV infection, and the investi- tion of antibiotic-resistant infections in hospitals. Structuredpopulationmodelsdistinguishindividualsfromoneanother- cording to characteristics such as age, size, location, status, and movement, to determine the birth, growth and death rates, interaction with each other and with environment, infectivity, etc. The goal of structured population models is to understand how these characteristics a?ect the dynamics of these models and thus the outcomes and consequences of the biological and epidemiolo- cal processes. There is a very large and growing body of literature on these topics. This book deals with the recent and important advances in the study of structured population models in biology and epidemiology. There are six chapters in this book, written by leading researchers in these areas.

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Epidemiology of Obesity in Children and Adolescents: Prevalence and Etiology

 Epidemiology  Comments Off on Epidemiology of Obesity in Children and Adolescents: Prevalence and Etiology
Oct 272019
 

Despite adults’ best preventive efforts, childhood obesity is on the rise in most areas of the world, and with it the prevalence of Type 2 diabetes, hypertension, cardiovascular disease, and other formerly adult-onset conditions. Epidemiology of Obesity in Children and Adolescents takes the global ecological approach that is needed to understand the scope of the problem and its multiple causes and mechanisms, and to aid in developing more effective prevention and intervention programs. In the book’s first half, experts present a descriptive summary of youth obesity trends in ten world regions, broken down by age group, gender, socioeconomic status, and risk factors. Complementing these findings, part two reviews the evidence base regarding the variables, separately and in combination, having the most significant impact on young people’s development of obesity, including:
• Genetic and nutrigenomic factors.
• Environmental and psychosocial factors, such as family shopping and eating habits and access to healthful foods.
• Neuroendocrine regulation.
• Prenatal and neonatal factors (e.g., gestational diabetes of the mother).
• Dietary factors, from nutrient content to young people’s food preferences.
• Physical activity versus sedentary behavior.
Epidemiology of Obesity in Children and Adolescents is necessary reading for the range of professionals involved in curtailing this epidemic, including public health specialists, epidemiologists, pediatricians, nurses, nutritionists, psychologists, health educators, and policymakers.

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Viral Infections of Humans: Epidemiology and Control Edition 5

 Epidemiology, Infectious Diseases  Comments Off on Viral Infections of Humans: Epidemiology and Control Edition 5
Oct 252019
 

Striking changes have occurred in the world since the publication of the last edition of Viral Infections of Humans. The global population is rapidly approaching 8 billion; climate change is leading to the introduction of new hosts, vectors and virus diseases heretofore never seen in many parts of the world; technological advances have revolutionized the ability to recognize and characterize viruses new and old; vaccines are altering the epidemiological landscape of the diseases they target, in some cases raising the hope of their eradication and remarkably powerful computational tools are enabling not only detection of outbreaks of disease much sooner than in the past but also, through complex mathematical modeling, more accurate prediction of their potential impact.
The new Fifth Edition of Viral Infections of Humans captures the both the excitement and frustration of the dynamic struggle between humankind and the viruses that continue to cause immense suffering. It presents the latest concepts, methods and technologies in epidemiology, detection, investigation, modeling and intervention. Updated and entirely new chapters by dozens of experts across the field provide analytic summaries of current knowledge of viruses and prions causing acute syndromes, chronic illnesses and/or malignancies. In sum, this ambitiously expanded volume offers a uniquely comprehensive perspective on viruses in humans, from agents of classic diseases (e.g., hepatitis, measles, polio, rabies and yellow fever), to those with greatest pandemic impact (e.g., influenza and human immunodeficiency virus), to those discovered relatively recently (e.g., henipavirus, metapneumovirus and norovirus).
The new Fifth Edition of Viral Infections of Humans is an invaluable reference for students, fellows and established professionals in the fields of microbiology, public health and infectious disease epidemiology, medicine and health policy.
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HIV/AIDS in China: Epidemiology, Prevention and Treatment

 Epidemiology  Comments Off on HIV/AIDS in China: Epidemiology, Prevention and Treatment
Oct 242019
 

With HIV becoming the leading cause of infectious-disease mortality in Mainland China, this book focuses on tackling HIV/AIDS in the face of rapid political and economic change in China. Featuring contributions by over a dozen leading figures in the field, this book is the go-to text for any student or reader interested in how national and international organizations’ are attempting to control this epidemic.
The book includes chapters on the epidemiology, treatment, and prevention of HIV, as well as several chapters that discuss in detail specific provincial- and national-level programs to control and treat HIV. It chronicles the Chinese government’s amazing about-face, as it replaced underfunded, non-evidence based policy decisions with successful, science-based approaches to disease control and prevention, including the adoption of once controversial needle-exchange programs and the establishment of a national HIV/AIDS data registry. It measures the success of national policy decisions, the implementation of treatment policies, and discusses the difficulty of accessing high-risk communities, including people who inject drugs, sex workers, and men who have sex with men – groups not easy to reach, study, engage in prevention programs, or treatment, for fear of stigmatization and loss of social status. Further, it documents the spread of HIV to other provinces, and the tragedy that befell repeat plasma donors in Henan and other poor provinces, where reused or improperly sterilized lab equipment caused some villages to have epidemic-level incidence rates. This book represents a positive contribution to the field of AIDS research, making vital, new information available to an interested readership.
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