Thoroughly updated to reflect major advances in the field of immuno-oncology, this second edition of Cancer Immunotherapy Principles and Practice, from the Society for Immunotherapy of Cancer (SITC), remains the definitive resource for information on tumor immunology and cancer immunotherapy treatments. An essential reference for both novice and experienced cancer researchers, oncologists, and related practitioners alike, the book not only guides readers through the fundamental scientific principles of the field all the way to translational and practical clinical applications for treating and managing oncologic disease, but also provides a comprehensive understanding of the regulatory processes that support the safe and effective delivery of immunotherapy to patients with cancer.
The expanded and updated second edition now spans 68 chapters, including 12 new chapters, covering major topics and innovations that have shaped the rapid development of immunotherapy and its ascension into the standard of care as first-line treatment for a growing number of disease settings. New to this edition are chapters with deeper insight into our understanding of cancer genomics and determinants of response, immunogenic cell death, cancer and stromal cell-intrinsic pathways of immune resistance, cancer immune exclusion, adoptive cell therapy, metabolomics, tumor mutation burden, immunotherapy in combination with radiation therapy, synthetic biology, and more. Complete with detailed illustrations, tables, and key points for targeted reference, Cancer Immunotherapy Principles and Practice, Second Edition is the most comprehensive and authoritative resource for scientists and clinicians looking to expand their knowledge base of this dynamic field.
Key Features:
- Offers key insights and perspectives on cancer immunology and immunotherapy treatments from renowned experts in the field
- Covers the basic principles and science behind cancer immunotherapy and tumor immunology
- Includes treatment strategies for a vast array of available immunotherapy classes and agents, such as cytokine therapies, oncolytic viruses, cancer vaccines, CAR T therapies, and combination immunotherapies
- Provides essential information on FDA-approved immunotherapies, including clinical management and outcome data related to response rates, risks, and toxicities
- Discusses special considerations for immunotherapy in the context of specific disease settings, including skin cancers, genitourinary cancers, gastrointestinal cancers, hepatocellular carcinomas, gynecologic malignancies, breast cancers, lung cancers, head and neck cancers, brain tumors, sarcomas, pediatric cancers, and treatments combined with radiation therapy
- Clarifies the complex regulatory aspects behind the development and approval of immunotherapy drugs
- Purchase includes access to the eBook for use on most mobile devices or computers
- Publisher: Springer Publishing Company
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The gold standard, with the most up-to-date research and resources
The treatment of cancer is being revolutionized by drugs that modulate the immune system, offering the prospect of long-term response and extended survival for many patients with advanced incurable cancer. A plethora of new drugs are being incorporated into current standards of care but many questions remain unanswered – and new ones emerge – about how to use these exciting new drugs to best effect. A good understanding of immune-oncology is therefore becoming increasingly important to keep up to date with this rapidly changing field. ‘Fast Facts: Immuno-Oncology’ takes you from the fundamentals of immunology through to the new concepts of immunoediting and immunotherapy and likely future directions. Whether you are a practicing oncologist, oncology health professional, medical student, cancer researcher or industry professional, this book provides all you need to know about immuno-oncology, concisely summarized. Contents: • Components of the immune system • How cancers evade the immune system • How cancer immunotherapy works • Clinical use of immune checkpoint inhibitors • The future of immuno-oncology • Useful resources
“This book is well written, concise, and easy to read and understand. It serves as a very handy and useful resource for busy laboratorians, who routinely encounter the situations detailed therein. It is also helpful for students, who need to learn how to recognize and avoid such situations, by providing expert guidance and examples of ways to keep these types of errors from potentially causing harm to patients.”–
This new edition of Clinical Immunology and Allergy is a practical and clinically based guide for clinicians and laboratory staff to aid diagnosis and management of immunological and allergic disease, and provides examples of the correct selection and interpretation of immunological tests for
The gold standard, with the most up-to-date research and resources
The Oxford Handbook of Clinical Immunology and Allergy is a unique, practical and clinically relevant guide for clinicians and laboratory staff to assist with the diagnosis and management of immunological/allergic disease, and the correct selection and interpretation of immunological tests.
Inflammation is important in many diseases, yet it is hard to find current information on the pertinent cellular and molecular mechanisms of inflammation. This book is a current and authoritative review of various aspects of inflammation in mammalian organisms. Basic principles, including regulation by cytokines, lipid mediators, reactive oxygen species and leukocyte recruitment are followed by chapters on integrative aspects of inflammation, such as neutrophil extracellular traps, sepsis and granulomatous inflammation.
This is the second and updated version of the